Synbiotic 365 Review – Pros and Cons, Side-Effects, and More!

Studies show that there are over 100 million cases of gastrointestinal issues treated in the US alone every single year. Despite how common they are, we don’t know a lot about how to treat them. Products companies have developed products like Synbiotic 365 to help alleviate these issues, but how do you know if you’re using the right one? Hopefully, we can help you answer this by looking at the pros and cons of Synbiotic 365 in this review.  

Synbiotic 365 review

What is Synbiotic 365?

Created by United Naturals, Synbiotic 365 is like the A-team of probiotics. Using a hard-core squad of the cream of the crop, good bacteria, Synbicotic 365 can rebalance your gut flora and get your digestive and physical health back on track so you can enjoy life to the full.

Synbiotic 365 contains a total of 20 billion probiotic and prebiotic cultures in every single capsule. That’s almost four times the number of people there are on earth.

In addition to this probiotic power, Synbiotic 365 also comes loaded with eight B-Vitamins, to help keep your energy levels and general well-being in peak state for day-to-day life.

Sound good? Well, it should. Let’s read on.

The Benefits of Synbiotic 365

The core benefits of Synb 365 are primarily based on digestive health. Suppose you suffer from bloating, cramping, flatulence, IBS-type symptoms, constipation, or diarrhea. In that case, this may well be the product for you, as a proper pro & prebiotic balance can potentially fix all of those issues. 

In addition to this, this supplement promises to redress energy level problems such as fatigue. This means that that lunchtime slump, or six o’clock slump, or ANYTIME SLUMP could potentially disappear, leaving you to get out there and smash your other life and fitness goals as you see fit.

Finally, and linked to the above, better digestion means better sleep. So if you have issues with sleeping due to bloating, cramps, or other similar problems, then this product may be what you’re looking for. 

We often think of sleep as a pillar of health, along with exercise and diet, but it’s the foundation of health. Addressing this seemingly simple issue can provide multiple incredible benefits throughout your waking life. 

Synbiotic 365 Ingredients

Let’s take a peek at this supplement’s formula and find out what’s behind the results that a lot of people are so in love with. The vitamins are as follows:

  • Thiamin (Vitamin B1)
  •  Riboflavin (Vitamin B2)
  •  Niacin (Vitamin B3)
  • Vitamin B6 (as pyridoxine HCI)
  • Folate (Vitamin B12), Biotin (Vitamin B7)
  • Pantothenic acid (Vitamin B5).

We always want to have a full range of B Vitamins in our body. They’re essential for proper health but can be challenging to obtain through diet alone. That’s why it’s great that Synbiotic 365 factored in this crucial building block for cell health. They boost energy levels, and they help your brain to work at an optimal level. So far, so good!

Now let’s look at the probiotic strains featured in this supplement and see if they pass the test:

Lactobacillus gasseri BNR-17

This probiotic is extracted from breast milk and has actually be shown to help control weight. 

OPTI-BIOME Bacillus subtilis MB-40

This strain helps break down food for energy. It’s also particularly resistant to the sulphuric acid found in your gut – feel the burn!

Bifidobacterium lactis BIO-4™ 

So this strain is about securing the lining of your gut. This prevents an illness known as leaky gut syndrome – basically when undigested food and other particles pass through the gut lining (at the site of the leak) and into the bloodstream. No thanks! It’s also a great aid in your immunity and inflammation control!

Lactobacillus paracasei Lpc-37™

This one is a big hitter for the old immune system. It achieves this by combatting unwanted bacteria and yeast infections – it also aids dental health in the same way! So this is like an antibiotic probiotic. 

Lactobacillus plantarum Lp-115™

Who needs iron? We need iron! And this is the guy to help us absorb it. It also reduces your blood pressure, improves your heart health, and aids digestion by increasing the speed at which food moves through your digestive tract. Wild!

Lactobacillus casei Lc-11™

This strain reduces IBS and Crohn’s Disease symptoms such as constipation. 

Lactobacillus reuteri  

This is a general anti-inflammatory working throughout the whole body while also keeping out nasty microbes of the pathogenic variety. Additionally, it also strengthens the intestinal lining!

Lactobacillus salivarius Ls-33™

This fast-growing strain helps block out harmful bacteria and boost your immune system.

Lactobacillus rhamnosus Lr-32™

Now Synbiotic 365’s coming in big on IBS prevention. This strain aids symptoms associated with the illness (as well as diarrhea & UTIs (urinary tract infections) by colonizing the intestinal walls. A great strain to have on your team.  

Lactobacillus fermentum 

We know antioxidants are good for us, right? Those fantastic little substances that go around snapping up free radicals in your body to help protect you? Well, Lactobacillus fermentum shares a lot of those properties. The result? You end up healthier with a much boosted immune system. 

It also raises ‘good’ cholesterol while lowering ‘bad’ cholesterol, enhances your liver’s detoxing power, improves your brain function and mood. As if that isn’t enough, it also helps you to absorb certain minerals much more efficiently!

Bifidobacterium bifidum Bb-06™ 

Again, these strains don’t stop packing benefits! In the case of Bifidobacterium bifidum Bb-06 vs. things you don’t want in your body, she can help out against lung infection-related symptoms, as well as those brought on by IBS and Crohn’s. And get this, it also can heal the gut lining, particularly following infection or illness.

Bifidobacterium longum Bl-05™ 

This one stabilizes your gut flora! It also lessens the effects of infectious, gastrointestinal, and immunological diseases. 

I think we all need a little break after that onslaught of excellent benefits! Go have a sip, and we’ll meet back here in five to talk through some final points! 

Synbiotic 365 Side Effects

Side effects-wise, some customers had reported increased bloating, and gastrointestinal discomfort before their existing symptoms improved. This is a widespread occurrence for any supplement like this.

As ever, even though this product looks relatively safe & natural, we would always encourage you to speak to your doctor or other health care practitioner before embarking on a stack like this.

How Do I Take Synbiotic 365?

This is the most straightforward bit of the whole product! All you do is take one Synbiotic 365 capsule daily. 

Some customers report results within as little as a few days, with some taking as long as a month to fully feel the results. We suggest tracking your symptoms/general state of health throughout supplementation.

Customer Synbiotic 365 Reviews

Overall, we were only able to find positive reviews regarding Synbiotic 365 during our standard internet trawl. While some customers had gripes about pill size, the cost, and the occasional initial increase in gastrointestinal issues in the first week, the product nonetheless looks pretty high quality and very well regarded. 

If you have a bad time with this, please let us know to add it to this review!

Where Can I Buy Synbiotic 365, and How Much Does it Cost?

You can buy Synbiotic 365 directly through the United Naturals website for $45.00 per box. In bulk, you can get three for $119 ($39.60 per box) or six or $429 ($38.16 per box). Each box contains 30 capsules, so either way, you’re looking at a minimum of $38.16/month.

You’ll be happy to know that yes! United Naturals do offer a 60 day money day back guarantee.

Additionally, you can get it at Amazon, though these won’t be subject to the 60-day money-back guarantee.

Synbiotic 365 –The Pros & Cons

Now that we know a bit more about the product let’s look at the positive and negative aspects of Synbiotic 365.


  • According to customer reviews, a lot of people have noticed improved GI symptoms.  
  • It contains types of Vitamin B that are difficult to get enough of in your normal diet.
  • You only need to take one pill a day, a major improvement over other GI supplements.
  • There are minimal side effects, except bloating and other stomach issues early on.


  • Like other similar supplements, it’s expensive. $1 per day adds up pretty quickly.
  • Results vary from person to person, so you have to be patient when you start taking Symbiotic 365.  

Our Final Thoughts 

Apart from some minor negatives about cost and the pill’s size, if you’re seriously looking to increase your gut health, we don’t think you could do better than Synbiotic 365. This product does look to be the real deal – so even if it is a slight strain on your wallet, we would say that the pros easily outweigh the cons!

Good luck! And do let us know your experience should you give this supplement a whirl.

Synbiotic 365 Alternatives

If our Synbiotic 365 review hasn’t sold you, there are some great alternatives out there that you should consider.

Total Restore is a great alternative that focuses more on treating leaky gut syndrome to alleviate gastrointestinal issues.

Alan Behrens

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