Bio X4

Bio X4 Review – Benefits, Side Effects, Ingredients, and More

Obesity is affecting more and more people around the world every day. Many adults are overweight, putting their health at risk in many profound ways.

This issue has not gone unnoticed globally, most especially in the industries trying to help. The fitness industry has risen in popularity significantly over the last decade in response to this epidemic, providing a range of supports for people looking to lose weight.

However, the fitness and wellbeing industries often miss many critical areas that cause weight gains in the first place—providing only simplistic methods of reducing your weight. While there is incredible value in exercise and diet, that does not mean weight loss is limited only to these methods.

One method rising in popularity is probiotic supplements, which provide a range of benefits to help people shed weight with ease. Probiotics are nothing new and are often employed by people looking to stay in shape. However, several supplements are now designing themselves specifically to assist in the weight loss struggle.

A popular probiotic supplement is Bio X4, a formula of four powerful probiotic blends that assist in weight loss and provide a range of health benefits.

We wanted to learn more about Bio X4 and do a better job than many other Bio X4 reviews at understanding what the supplement provides, what’s inside it, and the science behind how probiotic supplements help with weight loss.

Read on to see our in-depth review of the Bio X4 weight loss supplement!

Bio X4

What is Bio X4, and who makes it?

Bio X4 is a probiotic weight loss supplement designed and manufactured by Nucific, a California-based supplement company that creates a range of nutritional supplements. The company operates on the mantra of their supplements being “100% natural and contain no preservatives, colorings, or synthetic fillers.”

Dr. Amy Lee designed Bio X4 to assist people with their weight loss efforts and provide a more intelligent solution to the obesity epidemic. The hope was that it would promote long-term results and lifestyle changes.

Dr. Amy Lee’s Bio X4 design focuses on a few key benefits for users, such as:

  • Controlling food cravings
  • Suppressing appetite
  • Enhancing the digestive process
  • Breaking up Insulin resistance
  • Reducing the symptoms of gas and bloating after eating
  • Restoring healthy gut flora

What are Probiotics?

Before we delve deeper into the Bio X4 formula and the science behind how it provides its benefits, we must understand the key factor behind a probiotic supplement, probiotics themselves.

Probiotics are live microorganisms (bacteria) in our bodies naturally and linked to various health benefits. Currently, companies employ them in a wide range of medical applications.

Studies into probiotics are pervasive and have yielded promising results in treating intestinal disorders like irritable bowel syndrome (IBS) and lactose intolerance. However, studies link them to improved blood pressure and cholesterol levels in the body, especially in older patients.

The reason for this is the intestine. Trillions of live bacteria live within our intestine and together form the gut microbiota. Gut microbiota works to maintain a natural balance between “Good” and “Bad” bacteria to help our bodies fight off poor health. 

Probiotics help to maintain that balance and restore it if your gut microbiota is unbalanced. 

The company behind Bio X4 claims that the supplement helps to fight off the “bad” bacteria within your intestine, which make you crave sugars, carbs, and other unhealthy foods that provide significant unneeded calories.

Bio X4 Ingredients 

Since Bio X4 is an all-natural supplement, we must look at the ingredients that make up their formula. You can tie the Bio x4 supplement’s effectiveness to the ingredients they have chosen to use.

There are four essential blends in Bio X4, which gives it the name. A range of ingredients makes up these blends, which are:

  • Digestive Enzyme Blend: Amylase, Bromelain, and Lipase
  • Craving Control Blend: Caralluma Fimbriata Extract
  • Weight Management Blend: EGCG Green Tea Extract 
  • Probiotic Blend: Lactobacillus Rhamnosus, Lactobacillus Acidophilus, Lactobacillus Plantarum, Bifidobacterium Lactis, and Bifidobacterium Animalis

Just looking at these blends won’t give us the best idea of their benefits. So, let’s break down each combination individually and look more closely at what they offer:

Digestive Enzyme Blend

Digestive Enzyme Blend’s focus is around protein molecules, which work to accelerate chemical reactions within the body.

Digestive enzymes work in the body to break down food into nutrients that absorb into the body.

Bio X4 contains several enzymes, which include:

  • Amylase: Works to break down sugars
  • Lipase: Works to break down fats
  • Bromelain: Works to break down proteins

The human body, more specifically the digestive system, naturally produces these enzymes. However, in some cases, the body’s amount will not be sufficient for a healthy gut, resulting in gastrointestinal symptoms, such as diarrhea and bloating.

This reason is why they include these ingredients and, by extension these enzymes, in the Digestive Enzyme Blend. 

Craving Control Blend

The Craving Control Blend uses an assortment of natural Indian plant extracts to help suppress your appetite. Several medical studies have shown that these extracts help suppress our hunger response and lead to a smaller waist and gut over a long span of use. 

Caralluma Fimbriata, another ingredient inside the blend, is linked to lowered body fat and a heightened metabolic rate while suppressing your appetite.  

However, also linked to Caralluma Fimbriata are symptoms like diarrhea and fluid loss. Both of these could also contribute to this weight loss, but this is not ideal. Several clinical trials have been conducted on animals to solidify the effectiveness of the ingredients. However, this doesn’t necessarily translate to human results. 

Weight Management Blend

The Weight Management Blend is a powerful antioxidant focused blend that includes ingredients like EGCG, a powerful antioxidant compound that naturally occurs in green tea.

Bio X4 contains EGCG due to its alleged ability to boost the body’s fat-burning activity as a thermogenic. Numerous medical studies link this compound to a higher metabolic rate. In several animal trials, it prevented obesity even when scientists fed animals surplus calories.

The link between animals and humans’ effects is again cloudy—a worrying trend in Bio X4’s weight loss approach. However, scientists have conducted several studies that align with weight loss goals. 

Probiotic Blend

The Probiotic Blend within Bio X4 is the central key ingredient for weight loss, providing a range of all-natural ingredients that work to improve gut microbes in the body. The removal of these “Bad” bacteria, and the introduction of the “Good” bacteria, has profound effects on our eating choices.

Ingredients such as Lactobacillus Acidophilus, Lactobacillus Rhamnosus, Lactobacillus Plantarum, Bifidobacterium Lactis, and Bifidobacterium Animalis all play a crucial role in the reversal of this “Bad” bacteria build up.  

It’s not clear in medical studies if this change within the body always leads to weight loss. Gut microbes do not always dictate people’s eating habits, instead often being influenced by patterns more than anything.

However, if you are committed to changing your eating habits, the Probiotic Blend within Bio X4 will offer significant support.

Is Bio X4 Safe? – Known Side-Effects

Bio X4 uses primarily natural ingredients, meaning there are fewer side-effects linked to the use of the supplement. 

However, if you’re under 18, pregnant, or breastfeeding, you shouldn’t take this product.  

Some people do experience some side effects, which include:

  • Diarrhea
  • Bloating
  • Excess Gas
  • Stomach Cramps

Check with your doctor if you’re worried about taking Bio X4, and stop taking it if you’re regularly experiencing these side effects.  

How Long Does it Take to Work?

Because Bio X4 uses a primarily all-natural approach to weight loss, there isn’t one answer to this question as the supplement requires time for its ingredients to absorb into the body.

To find some answers on this front, we looked deeper into the customer experience with the product finding a few key trends that seem to hold true.

The majority of people who use Bio X4 reported their weight dropping after the first month. With varying degrees of weight loss. Simultaneously, a small minority of users reported results after two months, and some reported no change at all.

How is Bio X4 Taken?

You should take a Bio X4 capsule before each meal of the day. If your lifestyle does not meet a typical three large meal regiment, make sure to take the supplement three times per day, with some food and water.

It’s essential always to take the supplement with a meal, as it helps significantly in the digestion of the ingredients inside. Taking the supplement without a meal can result in an upset stomach. 

Where Can I Buy Bio X4, and How Much Does it Cost?

You can buy Bio X4 directly from their website or Amazon. Both are trusted sellers. If you find a different retailer, do some research. The supplement market is full of counterfeits and knock-offs that look almost identical to the real product they’re imitating. 

One bottle of the supplement will cost you $99, though you can get a better deal if you bulk buy. 

Three bottles will cost you only $129, while six bottles will cost you $240. All orders come with free shipping attached to them, for most locations in the world.

Bio X4 – Refund Policy

Bio X4 comes with a 90-day money-back guarantee. If you do not see the results you are looking for, you can return the product with no questions asked. This policy shows a lot of confidence from Nucific about their product, which is a positive.  

What Are People Saying About It?

Supplement companies are excellent marketers, making it hard to get to the bottom of how a product performs. This is why we like to look at Bio X4 reviews from real users on a site like Amazon to see what people really think.

On Amazon, Bio X4 has an average review score of 3.9, which is on the higher end as far as most supplements.  

Many positive reviews do mention that it has helped them curb cravings and improve overall digestion. It isn’t a magic bullet for weight loss, but they’re happy with how it supports other weight loss efforts.

Most negative reviews seem to stem from an overall misunderstanding of the product. People complain that they noticed no weight loss, but that could have easily been from their exercise regiment. 

We noticed a few people complain that the product was expired, but that’s more likely an Amazon warehouse issue as they usually carry the product. If you’re worried about that, you should order directly from Nucific.

What Are Alternatives to Bio X4?

We’re guessing you’re reading this review because finding a probiotic weight loss supplement can be overwhelming. If Bio X4 isn’t for you, we have some tips to narrow down your search so you don’t get overwhelmed.

First, you should check for a Good Manufacturing Practice (GMP) certification to confirm that it’s a quality product. 

Second, only purchase from vendors that you know are reputable. Fake products are abundant, and you don’t want to waste your money on them. 

Now that you know what to look for, here are a few alternatives that you might like:

  • Perfect Biotics
  • Bio-Zyme
  • Pro-Bio
  • Align Probiotic

If you’re interested in other weight management and health supplements, you should check out these reviews:

Bio X4 Pros and Cons

The Bio X4 supplement takes an intelligent approach to weight loss, providing a range of significant benefits for those looking to shed a few extra kilos or pounds. Let’s take a moment to look more closely at the pros and cons of Bio x4.


  • Probiotics and other ingredients promote better digestion within the body.
  • It works to improve overall bowel regularity.
  • Many ingredients can boost your immune system, making you get sick less often.  
  • Bio X4 is a significant source of energy, both cognitively and physically.
  • It comes in a wide range of affordable packaging deals.
  • The product uses eco-friendly packaging.
  • Nucific a 90-day money-back guarantee, so if you aren’t getting the results you like, you can get your money back. 
  • The creators of Bio X4 offer a wide range of medical information for users to educate themselves on before use.
  • It is gluten, lactose, and allergen-free.


  • Many people find the price not justified for what the supplement accomplishes.  
  • If you like to shop locally, you’ll be hard-pressed to find Bio X4 in any local shops.  
  •  You only get the maximum benefits from the supplement after daily use for an extended period.
  • It is only a weight management supplement, which means you won’t lose weight by taking it. 
  • Several health benefits are not 100% proven in medical studies.
  • Side effects like diarrhea, bloating, gassiness, and stomach cramps can be pretty uncomfortable.  

The Final Verdict

Bio X4 is an exciting approach to weight loss, and it is undoubtedly providing a much different approach to helping people shed weight. Compared to many other weight loss supplements on the market, it’s not hard to see why Bio X4 is gaining a strong reputation.

With many of the ingredients that make up Bio X4’s blends only being shown to assist with weight loss in animal trials, we are not entirely sure that we can trust the supplement’s claims. However, a significant number of success stories behind the supplement suggest it does provide its advertised results.

We always recommend diet and exercise as your first step towards weight loss. If that isn’t working for you and you’re looking to take a proactive approach to your weight loss, Bio X4 could be a great choice to help manage cravings. You are always free to try the supplement and then return it if you are unhappy with it. 

Bio X4 Quick Questions & Answers

How long does it take to see the effects of Bio X4?

Most people report that it takes between 30 and 60 days to notice the effects of Bio X4, similar to similar supplements.  

How Do I Contact Customer Service?

You can reach Nucific customer service at or 888-679-5520 7 am – 5 pm Monday – Friday or 7 am – 4 pm PST Saturday – Sunday.

How Do I Make a Return?

If. you’re still within the 90-day money-back guarantee window, you can call or email Nucific customer service for a no questions asked refund.  

Do I have to Pay For Shipping?

If your order is over $50, shipping is free when you buy directly from the Nucific website. On Amazon, shipping depends on if you’re a Prime member or not.  

How Long Does It Take to Arrive?

When you order direct, the order should ship within 48 hours. On average, it takes about five business days to arrive at your door via the United States Postal Service (USPS).

Is there caffeine in Bio X4? 

There’s 10 mg of green tea in every serving, which contains small amounts of caffeine. If you’re caffeine sensitive, this product is probably not for you.  

Are there any dietary restrictions?

Bio X4 is not vegan, but is vegetarian, gluten-free, and lactose-free, so it fits most diets.  

How should I take Bio X4?

Most people should take one capsule with every meal. Others can take two every meal as long as they never exceed six per day.

Alan Behrens

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